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USES
Cas No. 111470-99-6.

Amlodipine is approved to treat high blood pressure and heart disease. This eMedTV segment discusses these and other amlodipine uses, including "off-label" uses of the drug, such as when the drug is used as a treatment for migraines.

The fatigue is getting old. During the first six weeks after starting chemo I had fatigue in short bursts during the first few days after a treatment. The accumulation of chemo seems to be taking its toll however. I haven't been able to overcome fatigue the past two and a half weeks. After sleeping seven hours I can sleep another two a few hours later. Its obvious the additional rest is necessary because insomnia is now a thing of the past.

avoid drinking alcohol while taking amlodipine. Alcohol can further lower your blood pressure and may increase some of the side effects of amlodipine.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. You may need to use blood pressure medication for the rest of your life.

Amlodipine is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Tell your doctor about all other heart or blood pressure medications you are taking.

Your chest pain may become worse when you first start taking amlodipine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

Amlodipine slows the movement of calcium through muscle cells in the walls of blood vessels. Calcium is required for these muscle cells to contract, thus amlodipine causes the muscle cells to relax. This causes the blood vessels to dilate.

Blood pressure depends on the force with which the heart pumps the blood, and on the diameter of blood vessels and the volume of blood in circulation. Blood pressure increases if the blood vessels are narrow or if the volume is high. Dilating the blood vessels in the extremities therefore decreases blood pressure.
             
The coronary arteries in the heart are also dilated by amlodipine, and this allows more blood, and therefore oxygen, to be delivered to the heart at any time. Overall the heart is required to use less effort to pump blood around the body, and is also given a greater oxygen supply. This prevents the pain of angina, which would normally be brought on because of a lack of oxygen supply to the heart.

Not to be used in

• Allergy to related calcium channel blockers (dihydropyridines)

• Angina not well controlled by medical treatment (unstable angina)

• Breastfeeding
• Failure of the heart to maintain adequate circulation of blood (cardiogenic shock)
• Narrowing of the main artery coming from the heart (aortic stenosis)
• Pregnancy

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

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