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Amlodipine besylate tablets

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HOME >> Pharmaceuticals API List 1 >> Amlodpine Besylates

amlodpine besylate CAS  No. 111470-99-6.
Amlodpine Besylates
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Cas No. 111470-99-6.

Chemical Structure :

amoldipine desylate Formula  :  C20H25ClN2O5.C6H6O3S


Synonyms  Amlodipine besilate; 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-
                  methyl-1,4-dihydropyridine benzenesulfonate

Molecular Formula  :  C20H25ClN2O5.C6H6O3S Molecular Weight 567.05 CAS Registry Number 111470-99-6.

Amlodpine  Besylates Description

Amlodipine besylate is the besylate salt of amlodipine, a long-acting calcium channel blocker.

Amlodipine besylate is chemically described as 3-Ethyl-5-methyl ()-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its molecular formula is C20 H25 ClN2 O5 C6 H6 O3 S, and its structural formula is:

Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. Amlodipine besylate tablets are formulated as white tablets equivalent to 2.5, 5 and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate anhydrous, magnesium stearate, microcrystalline cellulose, sodium starch glycolate, and stearic acid.

Amlodipine Besylate Precautions.


Since the vasodilation induced by amlodipine is gradual in onset, acute hypotension has rarely been reported after oral administration. Nonetheless, caution, as with any other peripheral vasodilator, should be exercised when administering amlodipine, particularly in patients with severe aortic stenosis.

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 Amlodipine Besylate

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