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HOME >> Pharmaceuticals API List 2 >> Oxaprozin >> Interaction

INTERACTION
Oxaprozin CAS number 21256-18-8

Oxaprozin may increase the blood levels of lithium by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.

Oxaprozin may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (reduction) of blood pressure.

When oxaprozin is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycoside is reduced. This may lead to more side effects from methotrexate or aminoglycoside.

Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid oxaprozin because oxaprozin also thins the blood, and excessive blood thinning may lead to bleeding.

Before taking oxaprozin, tell your doctor if you are taking any of the following drugs:

*cyclosporine
*lithium
*a blood thinner such as warfarin
*steroids
*aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as diclofenac , etodolac , fenoprofen , flurbiprofen , ibuprofen , indomethacin , ketoprofen , ketorolac , mefenamic acid , nabumetone , naproxen , piroxicam (Feldene), and others.

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