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Primidone tablet

HOME >> Pharmaceuticals API List 2 >> Primidone

Primidone CAS number 125-33-7

Primidone

CAS number 125-33-7 Primidone Formula C12H14N2O2

Systematic (IUPAC) name
5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione

Identifiers
CAS number 125-33-7
ATC code N03AA03
PubChem 4909
DrugBank APRD00549
ChemSpider 4740

Chemical data
Formula C12H14N2O2
Mol. mass 218.252 g/mol
Pharmacokinetic data
Bioavailability ~100%
Protein binding 25%
Metabolism Hepatic
Half life Primidone: 5-18 hours,
Phenobarbital: 75-120 hours,
PEMA: 16 hours
Time to reach steady state:
Primidone: 2-3 days,
Phenobarbital&PEMA 1-4weeks
Excretion Renal

Primidone is an anticonvulsant of the pyrimidinedioneclass whose active metabolites, phenobarbitaland phenylethylmalonamide are also anticonvulsants. It is used mainly to treat complex partial, simple partials, generalized tonic-clonic seizures, myoclonic, akinetic seizures and it has been a valuable alternative to propranolol in the treatment of essential tremor. Unlike other anticonvulsants such as carbamazepine and valproic acid, primidone is rarely used in the treatment of bipolar disorder or any other psychiatric problem. It is also not widely used in treatment of neuropathic pain, trigeminal neuralgia, or migraine. Primidone has been occasionally used to treat long QT syndrome, cerebral palsy, and athetosis.

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