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Betalactams Piperacillin >> Consumer Information
USES: This medication is used to treat a wide variety of bacterial
infections. This medication is a combination of 2 drugs. Piperacillin is a
penicillin-type antibiotic that works by stopping the growth of bacteria.
Tazobactam is an enzyme inhibitor (beta-lactamase inhibitor) that helps the
piperacillin work better.
This antibiotic treats only bacterial infections. It will not work for viral
infections (e.g., common cold, flu). Unnecessary use or misuse of any
antibiotic can lead to its decreased effectiveness.
HOW TO USE: This medication is mixed in IV fluid and given by
injection into a vein by a health care professional. Follow all instructions
for preparation and use of this product. Before using this product, check it
visually for particles or discoloration. If either is present, do not use
the liquid. If you have questions about the use of this medication,f you are
using the frozen pre-mixed solution, thaw the container at room temperature
or in the refrigerator. If the bag is thawed in the refrigerator, let it sit
at room temperature for at least 1 hour before using. Do not thaw by putting
in warm/hot water or microwaving. After thawing, shake well and squeeze the
container to check for leaks. Discard solution if the container leaks. Do
not re-freeze the solution after thawing. This medication is given slowly
over at least 30 minutes, usually every 6 hours or as directed by your
doctor. Give aminoglycosides (e.g., gentamicin) separately from this
medication. Do not mix together in the same IV fluid.
SIDE EFFECTS: Swelling, redness, pain, or soreness at the injection
site may occur. Dizziness, trouble sleeping, nausea, vomiting, diarrhea, or
headache may also occur. If any of these effects persist or worsen, tell
your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she
has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.
PRECAUTIONS: Before using piperacillin/tazobactam, tell your doctor
or pharmacist if you are allergic to either of the drugs; or to penicillin,
cephalosporin, or beta-lactam antibiotics; or to other beta-lactamase
inhibitors such as sulbactam; or if you have any other allergies.
Before using this medication, tell your doctor or pharmacist your medical
history, especially of: bleeding problems, cystic fibrosis, kidney disease,
This medication contains sodium. Consult your doctor or pharmacist if you
are on a salt-restricted diet or if you have a condition that could be
worsened by an increase in salt intake (e.g., congestive heart failure, high
Before having surgery, tell your doctor or dentist that you are using this
MISSED DOSE: If you miss a dose, use it as soon as you remember. If
it is near the time of the next dose, skip the missed dose and resume your
usual dosing schedule. Do not double the dose to catch up.
STORAGE: Before mixing, store vials at room temperature between 68-77
degrees F (20-25 degrees C). After mixing, store at room temperature or in
the refrigerator at 36-46 degrees F (2-8 degrees C). If stored at room
temperature, use/discard the mixed solution within 24 hours.