CAS Registry Number 107133-36-8
Assess renal function before and during treatment where appropriate.
Renovascular hypertension. Surgery/anaesthesia. Renal failure: the dose
should be cautiously adjusted in accordance with the creatinine clearance
(refer to complete data sheet). Symptomatic hypotension is rarely seen, but
is more likely in volume-depleted patients, those receiving diuretics, or
with the first two doses. In diuretic-treated patients, stop the diuretic 3
days before starting Coversyl (perindopril). A diuretic may later be given
in combination if necessary; potassium-sparing diuretics are not
recommended. Combination with neuroleptics or imipramine-type drugs may
increase the hypotensive effect. Serum lithium concentrations may rise
during lithium therapy.