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PHARMACOLOGY
Chemical Formulas
 
 
 Dextromethorphan  Pharmacology

Dextromethorphan is a synthetically produced substance that is related to codeine. It has central cough suppressant action but it does not feature the untoward effects of the opioids: it does not have analgesic, sedating or constipating effects. Its metabolism is genetically polymorphous, similar to the codeine metabolism. Since its metabolites can be traced in urine, dextrometorphan is suitable as a testing substance for the definition of the respective phenotype. The pharmacological potential of dextromethorphan does not appear to be completely exploited yet. According to more recent studies (performed predominantly on animals), the substance also has antiepileptic, neuroprotective, and antiparkinsonian properties.


Dextromethorphan is the d-isomer of the codeine analog of levorphanol and lacks the analgesic and addictive properties of other narcotics.

Dextromethorphan acts centrally on the brain's cough reflex and provides temporary relief of coughs due to bronchial irritation.

Dextromethorphan is approved by the FDA for use in the temporary relief of cough due to minor throat and bronchial irritation.


Dextromethorphan is an antitussive, preventing or relieving coughing.
Dextromethorphan is indicated for the relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.


The FDA is notifying the public about the danger associated with abuse of dextromethorphan, a synthetic ingredient found in many over-the-counter cough and cold remedies. Dextromethorphan is a safe and effective cough suppressant when used as indicated, but abuse can lead to serious adverse events such as brain damage, loss of consciousness, irregular heartbeat, seizures, and death. Although dextromethorphan abuse is not a new phenomenon, a new trend involves encapsulating pure powdered dextromethorphan and selling the product on the street. Recent deaths of five teenagers have been associated with the consumption of powdered dextromethorphan.

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