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Moxifloxacin Hydrochlorideis a synthetic broad spectrum antibacterial agent and is available as Tablets for oral administration and as I.V. for intravenous administration.

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Water for Injection

HOME >> Pharmaceuticals API List 2 >> Moxifloxacin Hcl >> Drug Description

DRUG DESCRIPTION
Moxifloxacin HCl CAS No.: 186826-86-8

Moxifloxacin Hydrochlorideis a synthetic broad spectrum antibacterial agent and is available as Tablets for oral administration and as I.V. for intravenous administration. Moxifloxacin, a fluoroquinolone, is available as the monohydrochloride salt of 1-cyclopropyl-7-[(S,S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3 quinoline carboxylic acid. It is a slightly yellow to yellow crystalline substance with a molecular weight of 437.9.

The inactive ingredients are microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, polyethylene glycol and ferric oxide.

Moxifloxacin Hydrochlorideis I.V. is available in ready-to-use 250 mL latex-free flexibags as a sterile, preservative free, 0.8% sodium chloride aqueous solution of moxifloxacin hydrochloride (containing 400 mg moxifloxacin) with pH ranging from 4.1 to 4.6. The appearance of the intravenous solution is yellow. The color does not affect, nor is it indicative of, product stability. The inactive ingredients are sodium chloride, USP, Water for Injection, USP, and may include hydrochloric acid and/or sodium hydroxide for pH adjustment. I.V. contains approximately 34.2 mEq (787 mg) of sodium in 250 mL.

Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Moxifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. For the treatment of bacterial conjunctivitis caused by susceptible strains

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