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Trandolapril tablet

HOME >> Pharmaceuticals API List 3 >> Trandolapril

Trandolapril CAS number 87679-37-6

Trandolapril

CAS number 87679-37-6

Formula Structure :

Systematic (IUPAC) name
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

Identifiers
CAS number 87679-37-6
ATC code C09AA10
PubChem 5484727
DrugBank APRD01269

Chemical data
Formula C24H34N2O5
Mol. mass 430.537 g/mol

Pharmacokinetic data
Bioavailability
Protein binding Trandolapril 80%
(independent of concentration)
Trandolaprilat 65 to 94%
(concentration-dependent)
Metabolism Hepatic
Half life 6 hours (trandolapril)
10 hours (trandolaprilat)
Excretion Fecal and renal

Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzymeinhibitor, trandolaprilat. Trandolapril is chemically described as (2S, 3aR, 7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl] hexahydro-2-indo-linecarboxylic acid, 1-ethyl ester. Its empirical formula is C24H34N2O5and M.W.= 430.54
Melting Point = 125°C

Trandolapril is used alone or in combination with other medications to treat high blood pressure. It is also used to improve survival in patients with heart failure after a heart attack. Trandolapril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

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