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HOME >> Pharmaceuticals API List 3 >> Valdecoxib >> Consumer Information

Valdecoxib CAS number 181695-72-7

Valdecoxib CAS number 181695-72-7

  Rarely, serious (possibly fatal) allergic reactions have occurred with valdecoxib, including skin reactions. Seek immediate medical attention if an allergic reaction occurs. Symptoms of an allergic reaction may include: rash, mouth sores, itching, swelling, dizziness, trouble breathing.

:  Valdecoxib is an oral drug that belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs are used primarily to treat pain and arthritis.

As a consequence, pain, swelling and tenderness of joints due to arthritis are reduced. Valdecoxib (like celecoxib and rofecoxib) differs from most other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood.

DOSING: For osteoarthritis or rheumatoid arthritis, the usual approved dose of valdecoxib is 10 mg once daily. For dysmenorrhea, the dose is 20 mg twice daily. Valdecoxib may be taken with or without food.

SIDE EFFECTS: The most common side effects of valdecoxib are headache, abdominal pain, diarrhea, nausea, flatulence and insomnia. Other side effects include fainting, kidney failure, heart failure, fluid retention, aggravation of hypertension, chest pain, ringing in the ears, deafness, stomach and intestinal ulcers, bleeding, blurred vision, anxiety, photosensitivity, weight gain, water retention, flu-like symptoms, drowsiness and weakness.

Very serious allergic reactions have been reported with valdecoxib. It is recommended that patients who experience a rash after beginning therapy with valdecoxib should discontinue valdecoxib immediately and seek the advise of their physician. Although valdecoxib is not a sulfonamide itself, it is recommended that patients with an allergy to sulfonamides should not take valdecoxib.

PRECAUTION : Before Using This Medicine.

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to valdecoxib, other nonsteroidal anti-inflammatory drugs, aspirin or other salicylates or sulfonamides. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Valdecoxib has not been studied in pregnant women. However, studies in animals have shown that valdecoxib causes birth defects and other problems. Valdecoxib may cause problems in the baby's heart and lungs and is not recommended late in pregnancy. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding— It is not known whether valdecoxib passes into human breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of valdecoxib in children with use in other age groups.

Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

If miss a dose : Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

Storage : Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and moisture.

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