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HOME >> Pharmaceuticals API List 4 >> Cefotaxime Sodium


Cefotaxime Sodium
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CAS Registry Number is 64485-93-4.

cefotaxime sodiumis a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate 72 (Z)-(o-methyloxime), acetate (ester). CLAFORAN contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of CLAFORAN range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5.

The CAS Registry Number is 64485-93-4.

Indications and Usage

Treatment of infections of lower respiratory tract including pneumonia, urinary tract, skin and skin structures, bone and joints; treatment of bacteremia/septicemia, CNS infections, intra-abdominal infections including peritonitis, gynecological infections including pelvic inflammatory disease, endometritis and pelvic cellulitis caused by susceptible strains of specific microorganisms; perioperative prophylaxis.

Side effects

Cefotaxime may cause side effects. If you are administering cefotaxime into a muscle, it may be mixed with lidocaine (Xylocaine) to reduce pain at the injection site. Tell your health care provider if any of these symptoms are severe or do not go away:

* diarrhea
* stomach pain
* upset stomach
* vomiting

If you experience any of the following symptoms, call your health care provider immediately:

* unusual bleeding or bruising
* difficulty breathing
* skin rash
* itching
* hives
* sore mouth or throat

Storage/Stability/Compatibility -

Cefotaxime sodium sterile powder for injection should be stored at temperatures of less than 30°C; protect from light. The commercially available frozen injection should be stored at temperatures no greater than -20°C. Depending on storage conditions, the powder or solutions may darken which may indicate a loss in potency.

Doses -


For susceptible infections:

a) Foals: 20 - 30 mg/kg IV q6h (Caprile and Short 1987)

Dosage Forms/Preparations/FDA Approval Status -

Veterinary-Approved Products: None

Human-Approved Products:

Cefotaxime Sodium Powder for Injection; 500 mg, 1 g (as cefotaxime), 2 g, 10 g;

Cefotaxime Sodium for Injection in 5% dextrose bags (50 ml)—frozen; 1 g, 2 g;

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