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HOME >> Pharmaceuticals API List 4 >> Cefuroxime Sodium


 

Cefuroxime Sodium
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CAS NO. 56238-63-2

FORMULA C16H15N4O8S

MOL WT. 446.38

H.S. CODE 2941.90


CLASSIFICATION : ANTIBOITICS / CEPHALOSPORINS

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White to slightly yellowish powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
STABILITY Stable under ordinary conditions.

APPLICATIONS

Cephalosporin: any of a group of broad-spectrum derived from species of fungi of the genus Cephalosporium and are related to the penicillins in both structure and mode of action but relatively penicillinase-resistant antibiotics. These antibiotics have low toxicity for the host, considering their broad antibacterial spectrum.

They have the active nucleus of beta-lactam ring which results in a variety of antibacterial and pharmacologic characteristics when modified mainly by substitution at 3 and 7 positions. Their antibacterial activities result from the inhibition of mucopeptide synthesis in the cell wall. They are widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and streptococcal infections. The cephalosporin class of antibiotics is usually divided into generations by their antimicrobial properties. Three generations of cephalosporins are recognized and the fourth has been grouped.

Each newer generation of cephalosporins has broader range of activity against gram-negative organisms but a narrower range of activity against gram-positive organisms than the preceding generation. The newer agents have much longer half-lives resulting in the decrease of dosing frequency. Accordingly, the third-generation cephalosporins can penetrate into tissues well, and thus antibiotic levels are good in various body fluids. Second-generation cephalosporins have broader spectrums of activity against gram negative coverage but less active against gram-positive organisms than first-generation agents.

Cefuroxime eliminates bacteria that cause many kinds of infections, including lung, skin, bone, joint, stomach, blood, and urinary tract infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Side effects

Cefuroxime may cause side effects. If you are administering cefuroxime into a muscle, it may be mixed with lidocaine  to reduce pain at the injection site. Tell your health care provider if any of these symptoms are severe or do not go away:

* diarrhea
* stomach pain
* upset stomach
* vomiting

If you experience any of the following symptoms, call your health care provider immediately:

* unusual bleeding or bruising
* difficulty breathing
* itching
* rash
* hives
* sore mouth or throat

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