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Cefuroxime Sodium
Cefuroxime Sodium
CAS NO. 56238-63-2
FORMULA C16H15N4O8S
MOL WT. 446.38
H.S. CODE 2941.90
CLASSIFICATION : ANTIBOITICS / CEPHALOSPORINS
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE White to slightly yellowish powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER
pH
VAPOR DENSITY
STABILITY Stable under ordinary conditions.
APPLICATIONS
Cephalosporin: any of a group of broad-spectrum derived from species of
fungi of the genus Cephalosporium and are related to the penicillins in both
structure and mode of action but relatively penicillinase-resistant
antibiotics. These antibiotics have low toxicity for the host, considering
their broad antibacterial spectrum.
They have the active nucleus of beta-lactam ring which results in a variety
of antibacterial and pharmacologic characteristics when modified mainly by
substitution at 3 and 7 positions. Their antibacterial activities result
from the inhibition of mucopeptide synthesis in the cell wall. They are
widely used to treat gonorrhea, meningitis, pneumococcal, staphylococcal and
streptococcal infections. The cephalosporin class of antibiotics is usually
divided into generations by their antimicrobial properties. Three
generations of cephalosporins are recognized and the fourth has been
grouped.
Each newer generation of cephalosporins has broader range of activity
against gram-negative organisms but a narrower range of activity against
gram-positive organisms than the preceding generation. The newer agents have
much longer half-lives resulting in the decrease of dosing frequency.
Accordingly, the third-generation cephalosporins can penetrate into tissues
well, and thus antibiotic levels are good in various body fluids.
Second-generation cephalosporins have broader spectrums of activity against
gram negative coverage but less active against gram-positive organisms than
first-generation agents.
Cefuroxime eliminates bacteria that cause many kinds of infections,
including lung, skin, bone, joint, stomach, blood, and urinary tract
infections. This medication is sometimes prescribed for other uses; ask your
doctor or pharmacist for more information.
Side effects
Cefuroxime may cause side effects. If you are administering cefuroxime into
a muscle, it may be mixed with lidocaine to reduce pain at the
injection site. Tell your health care provider if any of these symptoms are
severe or do not go away:
* diarrhea
* stomach pain
* upset stomach
* vomiting
If you experience any of the following symptoms, call your health care
provider immediately:
* unusual bleeding or bruising
* difficulty breathing
* itching
* rash
* hives
* sore mouth or throat
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