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CAS number 9012-26-4
Piperacillin sodium is derived from
The chemical name of piperacillin sodium is sodium
The chemical formula is C23H26N5NaO7S and the molecular weight is 539.5.
Piperacillin-tazobactam is a beta-lactam/beta-lactamase
inhibitor combination with a broad spectrum of antibacterial activity that
includes Gram-positive and -negative aerobic and anaerobic bacteria.
Piperacillin-tazobactam retains its in vitro activity against broad-spectrum
beta-lactamase-producing and some extended-spectrum beta-lactamase-producing
Enterobacteriaceae, but not against isolates of Gram-negative bacilli
harboring AmpC beta-lactamases.
Piperacillin-tazobactam has recently been reformulated to include
ethylenediaminetetraacetic acid and sodium citrate; this new formulation has
been shown to be compatible in vitro with the two aminoglycosides,
gentamicin and amikacin, allowing for simultaneous Y-site infusion, but not
with tobramycin. Multicenter, randomized, double-blinded clinical trials
have demonstrated piperacillin-tazobactam to be as clinically effective as
relevant comparator antibiotics.
Clinical trials have demonstrated piperacillin-tazobactam to be effective
for the treatment of patients with intra-abdominal infections, skin and soft
tissue infections, lower respiratory tract infections, complicated urinary
tract infections, gynecological infections and more recently, febrile
neutropenia. Piperacillin-tazobactam has an excellent safety and
tolerability profile and continues to be a reliable option for the empiric
treatment of moderate-to-severe infections in hospitalized patients.