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HOME >> Pharmaceuticals API List 4 >> Meropenem

Meropenem pdf api

CAS number 119478-56-7

Systematic (IUPAC) name
3-[5-(dimethylcarbamoyl) pyrrolidin-2-yl] sulfanyl-6- (1-hydroxyethyl)-4-methyl-7-oxo- 1-azabicyclo[3.2.0] hept-2-ene-2-carboxylic acid


CAS number 119478-56-7
ATC code J01DH02
PubChem 64778
DrugBank APRD01097

Chemical data

Formula C17H25N3O5S
Mol. mass 383.464 g/mol

Pharmacokinetic data

Bioavailability 100%
Protein binding Approximately 2%.

To reduce the development of drug-resistant bacteria and maintain the effectiveness ofmeropenem for injectionand other antibacterial drugs,should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

meropenem for injectionis a sterile, pyrogen-free, synthetic, broad-spectrum, carbapenem antibiotic for intravenous administration. It is (4R,5S,6S)-3-[[(3S,5S)-5- (Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1- azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate. Its empirical formula is C17H25N3O5S3H2O with a molecular weight of 437.52.

The solution varies from colorless to yellow depending on the concentration. The pH of freshly constituted solutions is between 7.3 and 8.3. Meropenem is soluble in 5% monobasic potassium phosphate solution, sparingly soluble in water, very slightly soluble in hydrated ethanol, and practically insoluble in acetone or ether.

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