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HOME >> API >> API List1 >> Anastrozole >> How To Use

ANASTROZOLE (CAS NO.: 120511-73-1)
HOW TO USE

The dose of ANASTROZOLE is one 1 mg tablet taken once a day. For patients with advanced breast cancer, ANASTROZOLE should be continued until tumor progression.

For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial ANASTROZOLE was administered for five years.

Patients with Hepatic Impairment: Hepatic metabolism accounts for approximately 85% of anastrozole elimination. Although clearance of anastrozole was decreased in patients with cirrhosis due to alcohol abuse, plasma anastrozole concentrations stayed in the usual range seen in patients without liver disease. Therefore, no changes in dose are recommended for patients with mild-to-moderate hepatic impairment, although patients should be monitored for side effects. ANASTROZOLE has not been studied in patients with severe hepatic impairment.

Patients with Renal Impairment: No changes in dose are necessary for patients with renal impairment.

Use in the Elderly: No dosage adjustment is necessary.

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