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HOME >> API >> API List1 >> Fosphenytoin Sodium

Fosphenytoin Sodium CAS number 93390-81-9

Fosphenytoin Sodium

Fosphenytoin Sodium Molecular Formula C16H13N2Na2O6P

Molecular Formula C16H13N2Na2O6P

Molecular Weight 406.24

Systematic (IUPAC) name
(2,5-dioxo-4,4-diphenyl-imidazolidin-1-yl)methoxyphosphonic acid

Identifiers

CAS number 92134-98-0

ATC code N03AB05
PubChem 56339
DrugBank APRD00241

Chemical data

Formula C16H15N2O6P
Mol. mass 362.274 g/mol
Pharmacokinetic data
Bioavailability 100% (IM)
Protein binding 95 to 99%
Metabolism Hepatic
Half life 15 minutes to convert to phenytoin
Excretion Renal (as phenytoin)

Fosphenytoin Sodium USP
Specification For : Fosphenytoin Sodium USP
Test Specification
Description A white or almost white crystalline powder
Identification A)IR
B)The retention time of peak obtained in the chromatogram of the Assay preparation responds to that in the chromatogram of the standard preparation obtained in the test of assay
C)Test for Sodium
pH Limit : Between 8.5-9.5
Water Limit : Between 21.7%-25.7%
Heavy Metals Limit : Max. 0.002%
Chromatographic Purity(BY HPLC) Max. 0.1% of Phenytoin is found
Max. 0.1% of the other impurity is found
Max. 0.5% of the total impurities is found
Organic Volatile Impurities Meets the requirements
Assay (BY HPLC)[on anhydrous basis] Limit : 98% - 102%

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