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HOME >> API >> API List1 >> Cefuroxime Axetil

cefuroxime axetil CAS number 55268-75-2

Formula C16H16N4O8S ,Cefuroxime Axetil
Cefuroxime Axetil
CAS number 55268-75-2

Formula C16H16N4O8S

Mol. mass 424.386 g/mol
ATC code J01DC02

PubChem 41375

DrugBank APRD00285

ChemSpider 4514699

Pharmacokinetic data

Bioavailability 37% on empty stomach, up to 52% if taken after food
Metabolism axetil moiety is metabolized to acetaldehyde and acetic acid
Half life 80 minutes
Excretion Urine 66-100% Unchanged

Systematic (IUPAC) name
4-(carbamoyloxymethyl)-8- [2-(2-furyl)-2-methoxyimino-acetyl]amino -7-oxo-

2-thia-6-azabicyclo[4.2.0]oct -4-ene-5-carboxylic acid

Chemically, cefuroxime axetil, the 1-(acetyloxy) ethyl ester of cefuroxime, is (RS)-1-hydroxyethyl (6R,7R)-7-[2-(2-furyl)glyoxyl-amido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2-carboxylate, 72-(Z)-(O-methyl-oxime), 1-acetate 3-carbamate. Its molecular formula is C20H22N4O10S, and it has a molecular weight of 510.48.

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