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HOME >> API >> API List1 >> Donepezil

Donepezil CAS Number 120014-06-4

Molecular Structure Donepezil

Synonyms 2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one,

Molecular Formula C24H29NO3

Molecular Weight 379.49

CAS Number 120014-06-4

Properties

Melting point 207 ºC

Water solubility 2.931 mg/L

CLINICAL PHARMACOLOGY

Current theories on the pathogenesis of the cognitive signs and symptoms of Alzheimer's Disease attribute some of them to a deficiency of cholinergic neurotransmission. Donepezil hydrochloride is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. There is no evidence that donepezil alters the course of the underlying dementing process.

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