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Carbamazepine taj API

HOME >> API >> API List1 >> Carbamazepine >> Drug Description

DRUG DESCRIPTION
CARBAMAZEPINE CAS No 298-46-4

Carbamazepine (5H-dibenzazepine-5-carboxamide) is an iminostilbene derivative with a tricyclic structure. It is an antiepileptic drug widely used for treatment of simple and complex partial seizures, trigeminal neuralgia, and bipolar affective disorder.

Carbamazepine selectively inhibits high frequency epileptic foci while normal neuronal activity remains undisturbed. Carbamazepine is absorbed erratically after oral administration because of its lipophilic nature. It has a large volume of distribution; peak plasma levels occur 4-8 hours postingestion but may take up to 24 hours to peak. The primary site of metabolism is the liver; its metabolite also is active, which may increase duration of the symptoms of toxicity.

Carbamazepine is an anti-seizure medication. Recurrent seizures (epilepsy) are divided into two main categories according to how much of the brain is involved, partial and generalized epilepsy (which includes petit mal, grand mal, and myoclonic epilepsy). Seizures are called "simple" if there is no loss of consciousness and "complex" if there is. Medicines that inhibit seizures are called anti-convulsants. Carbamazepine works as an anti-convulsant for partial and grand mal seizures by reducing or blocking certain responses in the brain. It is also used for treating trigeminal neuralgia. One dosage form, Equetro, has been approved for treating bipolar disorder.

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Acamprosate Calcium	Clomipramine Hcl	Alendronate Sodium	Clonazepam	Amitriptyline	Clopidogrel Bisulfate	Anastrozole	Danazol	Atomoxetine Hcl	Desloratadine	Balsalazide
Desmopressin Monoacetate	Bicalutamide	Divalproex Sodium	Budesonide	Dobutamine Hcl	Bupropion Hcl	Donepezil	Calcitonin	Dothiepin Hcl	Capecitabine	Entacapone
Carbamazepine	Eptifibatide	Carboplatin	Escitalopram HBr	Carisoprodol	Eszopiclone	Carvedilol	Finasteride	Cefuroxime Axetil	Flurbiprofen	Cisplatin
Fluticasone Propionate	Citalopram Hbr	Fluvoxamine Maleate	Fosphenytoin Sodium

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