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HOME >> API >> API List1 >> Cisplatin >> Side Effects

SIDE EFFECTS
Cisplatin CAS Number 15663-27-1

Many people have one or more of the following side effects with cisplatin

* Fatigue during and after treatment – most people find their energy levels are back to normal within 6 months to a year
* Feeling or being sick can be severe – it may begin a few hours after treatment and last for a few days. It is usually possible to control this side effect with anti-sickness injections and tablets but if you are still being sick, tell your doctor.
* Cisplatin can cause kidney damage – you will have blood tests before your treatment, to make sure your kidneys are able to cope with the drug. To help prevent damage it is important to drink plenty of water and you will have fluids into your vein before and after your treatment.
* You may not be able to hear some high-pitched sounds – this usually gets better on its own some time after the treatment ends
* This drug may have a harmful effect on a developing baby. You should not become pregnant or father a child while taking this drug. Discuss contraception with your doctor before having the treatment, if there is any possibility that you or your partner could become pregnant.
* A temporary drop in the number of blood cells made by your bone marrow, leading to the following side effects



Each person's reaction to chemotherapy is different. Some people have very few side effects, while others may experience more. The side effects described here will not affect everyone who is given cisplatin, and may be different if you are having more than one chemotherapy drug.

We have outlined the most common side effects and some of the less common ones, so that you can be aware of them if they occur. However, we have not included those that are very rare and therefore extremely unlikely to affect you. If you notice any effects which you think may be due to the drug but which are not listed in this information, please discuss these with your doctor or chemotherapy nurse.

Feeling sick (nausea) and being sick (vomiting) If you do feel sick this may begin a few hours after the treatment is given and last for up a few days. Your doctor can prescribe very effective anti-sickness (anti-emetic) drugs to prevent, or greatly reduce, nausea and vomiting. If the sickness is not controlled, or continues, tell your doctor; they can prescribe other anti-sickness drugs which may be more effective. Some anti-sickness drugs can cause constipation. Let your doctor or nurse know if this is a problem.

Your kidneys may be affected Usually this does not cause any symptoms, and the effect is generally mild. But, if the effect is severe the kidneys can be permanently damaged unless the treatment is stopped. For this reason your kidneys will be checked by a blood test before each treatment.

You will be given fluid into a vein before and after the treatment to keep your kidneys working normally. You may be asked to measure and record what you drink and the amount of urine that you pass. If you pass less urine than you usually do, it is important to tell your nurse or doctor.

If necessary, you may be given medicine to help you to pass urine. You may be asked to drink extra fluid, before and after treatment, and it is important to do this. Let your doctor know if this is a problem, for example, if you are feeling sick.

Numbness or tingling in hands or feet This is due to the effect of cisplatin on nerves and is known as peripheral neuropathy. You may notice that you have difficulty doing up buttons or similar fiddly tasks. Tell your doctor if you notice any numbness or tingling in your hands or feet. The side effect usually disappears slowly a few months after the treatment ends.

Changes in hearing You may have ringing in your ears (tinnitus) and may lose the ability to hear some high-pitched sounds. Again, this effect usually decreases when the treatment ends, although for a small number of people, it may be permanent. Tell your doctor if you notice any loss of hearing or tinnitus.

Temporary taste alterations A dietitian or specialist nurse at your hospital can give advice about ways of coping with this side effect.

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