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CAS Number 52663-81-7

HOME >> API >> API List1 >> Dobutamine Hcl >> Precautions

PRECAUTIONS
Dobutamine CAS Number 49745-95-1

1. During the administration of Dobutamine Injection, USP, as with any adrenergic agent, ECG and blood pressure should be continuously monitored. In addition, pulmonary wedge pressure and cardiac output should be monitored whenever possible to aid in the safe and effective infusion of Dobutamine hydrochloride.

2. Hypovolemia should be corrected with suitable volume expanders before treatment with Dobutamine hydrochloride is instituted.

No improvement may be observed in the presence of marked mechanical obstruction, such as severe valvular aortic stenosis.

Usage Following Acute Myocardial Infarction− Clinical experience with Dobutamine hydrochloride following myocardial infarction has been insufficient to establish the safety of the drug for this use. There is concern that any agent that increases contractile force and heart rate may increase the size of an infarction by intensifying ischemia, but it is not known whether Dobutamine hydrochloride does so.
Laboratory Tests

Dobutamine, like other β2-agonists, can produce a mild reduction in serum potassium concentration, rarely to hypokalemic levels. Accordingly, consideration should be given to monitoring serum potassium.

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