Ephedrine Hydrochloride USP
Ephedrine Hydrochloride USP
|Molecular Formula :
Molecular Weight :
CAS No. :
Chemical Name :
œ-[1-(methylamino)ethyl]-, hydrochloride [R-(R*,S* )], salt
(1R,2S)-2-Methylamino-1-phenyl propan-1-ol Hydrochloride
crystals or white crystalline powder
spectrum of sample is concordant with the reference
b) A solution of sample respond to the test for chloride.
soluble in water and soluble in alcohol.
Melting range :
and 220°C; the range between beginning and end of melting
does not exceed 2°C
Specific rotation :
33.0° and - 35.5° ( 5 % solution in water )
Acidity & alkalinity :
||NMT 0.10 ml
of 0.02 N H2SO4 or NMT 0.20 ml of 0.02 N
||Must pass the
test. No turbidity develops within 10 min.
Ordinary impurities :
||NMT 2.0 %
Residue on ignition :
||NMT 0.1 %
on drying :
||NMT 0.5 %
Organic volatile impurities :
||Must pass the test
||Between 98.0 % and 100.5 % (
dried basis )
Therapeutic indications :
Packed in double lined polyethylene bags in 25 kg
Store below 35°C.
(EPH) is a sympathomimetic amine commonly used as a stimulant,
appetite suppressant, concentration aid, decongestant, and to treat
hypotension associated with anaesthesia. Ephedrine is similar in
structure to the synthetic derivatives amphetamine and
methamphetamine. Chemically, it is an alkaloid derived from various
plants in the genus Ephedra (family Ephedraceae). It is most usually
marketed in the hydrochloride and sulfate forms.
Ephedrine exhibits optical isomerism and has two chiral centres. By
convention the enantiomers with opposite stereochemistry around the
chiral centres are designated ephedrine, while pseudoephedrine has
same stereochemistry around the chiral carbons. That is, (1R,2R)-
and (1S,2S)-enantiomers are designated pseudoephedrine; while
(1R,2S)- and (1S,2R)-enantiomers are designated ephedrine.
The isomer which is marketed is (-)-(1R,2S)-ephedrine.
As with other phenylethylamines, it is also somewhat chemically
similar to methamphetamine, although the amphetamines are more
potent and have additional biological effects.
These terms are used to refer to the same substance derived from the
plant Ephedra. (There are many common names for these evergreen
plants, including squaw tea and Mormon tea.) Ephedra is a shrub-like
plant that is found in desert regions in central Asia and other
parts of the world. The dried greens of the plant are used
medicinally. Ephedra is a stimulant containing the herbal form of
ephedrine, an FDA-regulated drug found in over-the-counter asthma
In the United States, ephedra and ephedrine are sold in health food
stores under a variety of brand names. Ephedrine is widely used for
weight loss, as an energy booster, and to enhance athletic
performance. These products often contain other stimulants, such as
caffeine, which may have synergistic effects and increase the
potential for adverse effects. Ephedra is often touted as the
Ephedra's main active medical ingredients are the alkaloids
ephedrine and pseudoephedrine. The ephedras also contain various
tannins and related chemicals.The stem contains 1-3% total
alkaloids, with ephedrine accounting for 30-90% of this total. The
concentrations of these alkaloids depends upon the particular
species of ephedra used.
Ephedrine Sulphate (1932) Ephedrine Compound (1932) and Swan-Myers
Ephedrine Inhalant No. 66 (ca. 1940)
In traditional Chinese medicine, ephedrine has been used in the
treatment of asthma and bronchitis for centuries.
An ECA stack is a component found in thermogenic weight loss pills,
composed of ephedrine, caffeine and aspirin (many supplement
manufacturers include salicin instead of aspirin) working to speed
up the metabolism and thus cause food energy to burn faster. The ECA
stack is a popular supplement taken by body builders before workouts
due to the increased amount of energy and alertness.
Recreational and illicit use
Anecdotal reports have suggested that ephedrine helps studying,
thinking, or concentrating to a greater extent than caffeine. Some
students and some white-collar workers have used ephedrine (or
Ephedra-containing herbal supplements) for this purpose, as well as
some professional athletes and weightlifters. It is common for many
athletes to use stimulants while exercising. Such use of ephedrine
has been associated with stimulant dependence, as well as deaths
from heatstroke in athletes and circulatory problems such as aortic
aneurysm in weightlifters, though these side effects are rare.As a
phenylethylamine, ephedrine has a similar chemical structure to
amphetamines. Ephedrine can be used in the synthesis of
methamphetamine by chemical reduction; this has made ephedrine a
highly sought-after chemical precursor in the illicit manufacture of
methamphetamine. The most popular method for reducing ephedrine to
methamphetamine is similar to the Birch reduction, in that it uses
anhydrous ammonia and lithium metal in the reaction. The second most
popular method uses red phosphorus, iodine, and ephedrine in the
These API/ chemicals are designated as those that are used in
the manufacture of the controlled substances and are important to
the manufacture of the substances. For any (Control Substance)
products Import and Export *** subjected to your country government
laws /control substance ACT.
Note /Government Notification:
These chemicals are designated as those that are used in the
manufacture of the controlled substances and are important to the
manufacture of the substances. For any (Control Substance) products
Import and Export *** subjected to your country government laws
/control substance ACT.
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|(l) - Ephedrine Sulphate
||[ 134 - 72 - 5 ]
|(l) - Ephedrine Base Anhydrous
||[ 299 - 42 - 3 ]
|(l) - Ephedrine Base
||[ 50906 - 05 - 3 ]
|(d) - Ephedrine Hydrochloride
||[ 24221 - 86 - 1 ]
|(d) - Ephedrine Base
||[ 144429 - 10 - 7 ]