Name Zolpidem tartrate
Molecular Structure : Zolpidem tartrate,
CAS No. : : 99294-93-6
Molecular Formula : 2(C19H21N3O).C4H6O6
Molecular Weight : 764.88
Zolpidem is a prescription medication used for the
short-term treatment of insomnia, as well as some brain
disorders. It is a short-acting nonbenzodiazepine hypnotic that
potentiates gamma-aminobutyric acid (GABA), an inhibitory
neurotransmitter, by binding to gamma-aminobutyric acid (GABAA)
receptors at the same location as benzodiazepines It works quickly
(usually within 15 minutes) and has a short half-life (2–3 hours).ts
hypnotic effects are similar to those of the benzodiazepine class of
drugs, but it is molecularly distinct from the classical
benzodiazepine molecule and is classified as an imidazopyridine.
Flumazenil, a benzodiazepine receptor antagonist, which is used for
benzodiazepine overdose, can also reverse zolpidem's
sedative/hypnotic and memory impairing effects.As an anticonvulsant
and muscle relaxant, the beneficial effects start to emerge at 10
and 20 times the dose required for sedation, respectively. For
that reason, it has never been approved for either muscle relaxation
or seizure prevention. Such drastically increased doses are more
inclined to induce one or more negative side-effects, including
hallucinations and/or amnesia.
Zolpidem tartrateis a non-benzodiazepine hypnotic of the
imidazopyridine class and is available in 5 mg and 10 mg strength
tablets for oral administration.Zolpidem tartrate is a white to
off-white crystalline powder that is sparingly soluble in water,
alcohol, and propylene glycol.
zolpidem tartrateis indicated for the short-term treatment of
insomnia characterized by difficulties with sleep initiation.
DOSAGE AND ADMINISTRATION
The doseshould be individualized.
Dosage in adults
The recommended dose for adults is 10 mg once daily immediately
before bedtime. The total Ambien dose should not exceed 10 mg per
Elderly or debilitated patients may be especially sensitive to the
effects of zolpidem tartrate. Patients with hepatic insufficiency do
not clear the drug as rapidly as normal subjects. The recommended
dose of Ambien in both of these patient populations is 5 mg once
daily immediately before bedtime
Use with CNS depressants
Dosage adjustment may be necessary when Ambien is combined with
other CNS depressant drugs because of the potentially additive
The effectbe slowed by ingestion with or immediately after a meal.
HOW TO USE
Take this medication by mouth, usually once nightly immediately
before bedtime on an empty stomach, or as directed by your doctor.
Do not take it with food because the effect of the medication will
Dosage is based on your medical condition, age, and response to
therapy. Do not take more than 10 milligrams per day.
Although unlikely, this drug can infrequently cause temporary memory
loss. To avoid this effect, do not take a dose of this drug unless
you have time for a full night's sleep that lasts at least 7-8
hours. For example, do not take zolpidem during an overnight plane
flight of less than 8 hours. SIDE EFFECTS: Dizziness,
lightheadedness, headache, upset stomach, diarrhea, and dry mouth
may occur. To minimize the risk of falls, remember to get up slowly
when rising from a seated or lying position. If any of these effects
persist or worsen, notify your doctor or pharmacist promptly.
This medication may make you sleepy during the day. Tell your doctor
if you have daytime drowsiness. Your dose may need to be adjusted.
Rarely, after taking this drug, people have gotten out of bed and
driven vehicles while not fully awake ("sleep-driving"). People have
also sleepwalked, prepared/eaten food, made phone calls, or had sex
while not fully awake. Often, these people do not remember these
events. If you discover that you have experienced any of these
events, tell your doctor immediately. A very serious allergic
reaction to this drug is unlikely, but seek immediate medical
attention if it occurs. Symptoms of a serious allergic reaction may
include: rash, itching, swelling (especially of the face, lips,
tongue, or throat), severe dizziness, trouble breathing.
Before using this medication, tell your doctor or pharmacist your
medical history, especially of: kidney disease, liver disease,
mental/mood problems (e.g., depression), personal or family history
of regular use/abuse of drugs/alcohol/other substances,
lung/breathing problems (e.g., chronic obstructive pulmonary
disease-COPD, sleep apnea), a certain muscle disease (myasthenia
This drug may make you dizzy or drowsy; use caution engaging in
activities requiring alertness such as driving or using machinery.
Avoid alcoholic beverages because they may increase the risk of this
drug's side effects.
Store at room temperature between 68-77 degrees F (20-25 degrees C)
away from light and moisture. Do not store in the bathroom. Keep all
medicines away from children.
Abnormal thinking and behavioral changes
A variety of abnormal thinking and behavior changes have been
reported to occur in association with the use of sedative/hypnotics.
Some of these changes may be characterized by decreased inhibition
(e.g., aggressiveness and extroversion that seemed out of
character), similar to effects produced by alcohol and other CNS
depressants. Visual and auditory hallucinations have been reported
as well as behavioral changes such as bizarre behavior, agitation
and depersonalization. In controlled trials, < 1% of adults with
insomnia who received zolpidem reported hallucinations. In a
clinical trial, 7.4% of pediatric patients with insomnia associated
with attentiondeficit/hyperactivity disorder (ADHD), who received
zolpidem reported hallucinations
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manufacture of the controlled substances and are important to the
manufacture of the substances. For any (Control Substance) products
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