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Ergotamine
CAS number 113-15-5

Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline.

It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.

It is used medicinally for treatment of acute migraine attacks (sometimes in combination with caffeine), and to induce childbirth and prevent post-partum haemorrhage.


Systematic (IUPAC) name
(6aR,9R)-N-((2R,5S,10aS,10bS)- 5-benzyl-10b-hydroxy-2-methyl- 3,6-dioxooctahydro-2H-oxazolo[3,2-a] pyrrolo[2,1-c]pyrazin-2-yl) -7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg] quinoline-9-carboxamide

Identifiers

CAS number 113-15-5
ATC code N02CA02
PubChem 9787
ChemSpider 7930

Chemical data

Formula C33H35N5O5
Mol. mass 581.66 g/mol

This belongs to the group of medicines known as Ergot Alkaloids

Ergotamine is used to treat migraine headaches and some other types of throbbing headaches.

Research has shown that migraine can be caused by the swelling of blood vessels around the brain. Ergotamine eases the pain associated with migraine by narrowing these blood vessels.

Ergotamine is available combined with caffeine or other ingredients, in tablet and suppository form.

Ergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Ergotamine also affects blood flow patterns that are associated with certain types of headaches.

Ergotamine is used to treat a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your ususal migraine headaches.

How to store Ergotamine

Keep out of reach of children.
Store in a cool, dry place, away from direct light and heat.
 

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