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Para Methoxy Phenyl Acetic Acid

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CAS Registry Number: 104-01-8
Para Methoxy Phenyl Acetic Acid















 

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


 

 

 

 

 

 

 

 

 

 

 

 


 

 

 

 

 

 

 

HOME >> Chemicals >> Para Methoxy Phenyl Acetic Acid

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Para Methoxy Phenyl Acetic Acid


Para Methoxy Phenyl Acetic Acid structure


IUPAC Name:
2-(4-methoxyphenyl)acetic acid

Synonyms:
Homoanisic acid, Benzeneacetic acid, 4-methoxy-, p-Methoxyphenylacetic acid, 2-(p-Anisyl)acetic acid, MOPA, 4-Methoxyphenylacetic acid, 4-Methoxybenzeneacetic acid, (4-Methoxyphenyl)acetic acid, Acetic acid, (p-methoxyphenyl)-, Acetic acid, p-methoxyphenyl-, WLN: QV1R DO1, NCIOpen2_000187, (p-Methoxyphenyl)acetic acid, M19201_ALDRICH, EINECS 203-166-4, NSC 27799, AIDS017837, P-METHOXYPHENYLACETIC ACID, AIDS-017837, NSC27799

CAS Registry Number: 104-01-8

Molecular Formula: C9H10O3

Molecular Weight: 166.173900 [g/mol]

H-Bond Donor: 1 H-Bond Acceptor: 3

Melting Point : 84-86 C(lit.)
Boiling Point : 140 C3 mm Hg(lit.)
Fp : 193C
Water Solubility : 6 g/L (20 C)
TOXICITY
Oral rat LD50: 1550 mg/Kg
STABILITY : Stable under ordinary conditions

DESCRIPTION & APPLICATIONS

Phenylacetic acid is a white crystals with a disagreeable odor; boiling point 262 C; soluble in alcohol and ether. It serves as an ingredient in perfume to provide honey-like odor. It is found as a moiety in some alkaloids and plant hormones. It is formed as catabolite of phenylalanine. Substituted phenylacetic acid molecule at alpha position and phenylacetate esters can serve as a drug with a wide variety of effects including anticholinergic, muscarinic antagonist, antidote to cholinesterase inhibitors or toxins, cycloplegic and mydriatic. Phenylacetic acid is used to prepare a nonsteroidal antiinflammatory drug like diclofenac. It is used the manufacture of penicillin. Mandelic Acid, phenylglycollic acid, can be produced from phenylchloracetic acid.

4-Methoxyphenylacetic Acid is used as an intermediate for pharmaceuticals (especially for dextromethorphan) and other organic synthesis. It is used as a plant growth regulator and herbicide.

SPECIFICATION

APPEARANCE white to off-white powder

ASSAY 99.0% min
CLARITY IN ETHANOL clear

Phenylacetic acid definition - medical
An abnormal product of phenylalanine catabolism that appears in the urine in phenylketonuria.

Synthesis of Phenylacetic Acid

Phenylacetic Acid from Benzyl Chloride

10% of a solution of 125 g benzyl chloride [1] in 250 ml of sodium-distilled diethyl ether is added to 24 g magnesium turnings under 100 ml ether, and a small iodine crystal is added. after start of the grignard reaction the rest of the benzyl chloride is added with stirring to maintain gentle boiling (if the reaction becomes too vigorous, useless 1,2-diphenylethane is formed) and the mixture is heated and stirred until most magnesium is dissolved. The grignard reagent solution is poured on 1 kg water-free, crushed dry ice (solid CO2) and stirred for 2 hrs. 200 ml warm ether is added and the mixture is heated in a water-bath until the internal temperature reaches 25C. 200 ml 32% hydrochloric acid is added, and the heterogenous mixture stirred until any inorganic precipate is dissolved. after filtering, the organic layer is separated, washed with cold water, and dried over 20 g anhydrous sodium sulfate. The ether is distilled off, and the rest is recrystallized from water, to yield 75% - about 100g - phenylacetic acid, mp 76-77C.

Phenylacetic acid from Benzyl Cyanide
In a silica basin of about 35 cm. diameter, a mixture of 2.5 kilos of benzyl cyanide [3] and 7.5 kilos of 70% sulfuric acid is warmed until a few bubbles of gas appear. The heating is at once stopped, since a very vigorous action now ensues. As the vapors evolved are injurious to health, the basin is covered when the reaction begins with a sliding cover from which the vapors can be led into water. As soon as the reaction ceases, the product is poured upon crushed ice in a large, earthenware vessel. Crude phenyl acetic acid, contaminated on the surface with phenyl acetamide, is precipitated on cooling. In order to remove the amide, the acid is dissolved in lukewarm dilute soda solution. The amide remains undissolved and can be filtered off, while the phenyl acetic acid goes into solution as sodium salt and is reprecipitated in a sufficiently pure state by the addition of dilute mineral acid. After drying it is acceptably pure.

APPEARANCE Para Methoxy Phenyl Acetic Acid

Note: These API/ chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances. For any (Control Substance) products Import and Export *** subjected to your country government laws /control substance ACT.

Note /Government Notification:  N/A

 
               
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Molecular Formula: C9H10O3 Para Methoxy Phenyl Acetic Acid
Para Methoxy Phenyl Acetic Acid DESCRIPTION


 


 


 


 

 

 

 

 

 

 

 

 

 

 


 

Para Methoxy Phenyl Acetic Acid

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