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HOME >> Pharmaceuticals API List 3 >> Quetiapine Fumarate >> Dosage

Quetiapine Fumarate CAS number 111974-69-7
 
DOSAGE
Quetiapine Fumarate CAS number 111974-69-7


Acute Bipolar Mania
Adults

PO 100 mg/day in 2 divided doses on day 1; increase to 400 mg/day on day 4 in increments of up to 100 mg/day in 2 divided doses. Further dosage adjustments of up to 800 mg/day by day 6 should be in increments of no more than 200 mg/day.
Depression
Adults

PO Start with 50 mg once daily at bedtime. Increase to 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. If indicated, the dose may be increased to 400 mg on day 5 and 600 mg on day 8.
Maintenance in Bipolar I Disorder
Adults

PO Generally, in the maintenance phase, patients are continued on the same dose on which they were stabilized during dose stabilization.
Schizophrenia
Adults

PO  25 mg twice daily initially; may increase in increments of 25 to 50 mg twice daily to 3 times daily on days 2 and 3 to target range of 300 to 400 mg/day by day 4. Increase dose every 2 days by 25 to 50 mg twice daily as indicated. Therapeutic dose range is 150 to 750 mg/day.
Adults

PO  Start with 300 mg once daily, preferably in the evening. Dose increases can be made at daily intervals in increments of up to 300 mg/day. Dosages above 800 mg/day have not been evaluated.
Elderly/Hepatic Function Impairment
Adults

PO Start with 25 mg/day; increase in daily increments of 25 to 50 mg/day to an effective dose.
General Advice

* Safety of dosages higher than 800 mg/day has not been evaluated.
* Take without regard to meals. Take with food if stomach upset occurs.
* Long-term use (more than 6 wk) not evaluated. Periodically reevaluate usefulness.
* When restarting patients who have had an interval of less than 1 wk off quetiapine, resume maintenance dose. If the interval is more than 1 wk, follow initial titration period.
*  tablets should be swallowed whole and not split, chewed, or crushed.
*  should be taken without food or with a light meal (about 300 calories).
* Use immediate-release tablet for schizophrenic patients requiring less than 200 mg per dose of  during the initial titration.
* Start schizophrenic elderly patients and/or patients with hepatic function impairment on the immediate-release formulation. Dose can be incrementally increased daily. When an effective dose has been reached, the patient may switch to an equivalent total daily dose of the ER formulation.
* Schizophrenic patients currently treated with divided doses of the immediate-release formulation may be switched to equivalent total daily doses of the ER formulation taken once daily.
* Consideration should be given to a slower rate of dose titration and a lower target dose in elderly patients and in patients who are debilitated or who are predisposed to hypotension.

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Quetiapine Fumarate

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