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Trandolapril

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HOME >> Pharmaceuticals API List 3 >> Trandolapril

Trandolapril CAS number 87679-37-6

Trandolapril pdf api

CAS number 87679-37-6

Formula Structure :
Trandolapril Formula C24H34N2O5
Systematic (IUPAC) name
(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

Identifiers
CAS number 87679-37-6
ATC code C09AA10
PubChem 5484727
DrugBank APRD01269

Chemical data
Formula C24H34N2O5
Mol. mass 430.537 g/mol

Pharmacokinetic data
Bioavailability
Protein binding Trandolapril 80%
(independent of concentration)
Trandolaprilat 65 to 94%
(concentration-dependent)
Metabolism Hepatic
Half life 6 hours (trandolapril)
10 hours (trandolaprilat)
Excretion Fecal and renal

Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzymeinhibitor, trandolaprilat. Trandolapril is chemically described as (2S, 3aR, 7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl] hexahydro-2-indo-linecarboxylic acid, 1-ethyl ester. Its empirical formula is C24H34N2O5and M.W.= 430.54
Melting Point = 125C

Trandolapril is used alone or in combination with other medications to treat high blood pressure. It is also used to improve survival in patients with heart failure after a heart attack. Trandolapril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

Information Associated with Product:
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SIDE EFFECTS
PRECAUTIONS
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CONSUMER INFORMATION
 
 
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Trandolapril

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