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Ramiprilis

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HOME >> API >> API List 3 >> Ramipril

Ramiprilis  CAS number 87333-19-5

Ramipril pdf api
CAS number 87333-19-5

Ramipril Formula C23H32N2O5
Systematic (IUPAC) name
(2S,3aS,6aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid

Identifiers
CAS number 87333-19-5
ATC code C09AA05
PubChem 5362129
DrugBank APRD00009
ChemSpider 4514937

Chemical data
Formula C23H32N2O5
Mol. mass 416.511 g/mol
SMILES eMolecules & PubChem

Pharmacokinetic data
Bioavailability 28%
Protein binding 73% (ramipril)
56% (ramiprilat)
Metabolism Hepatic, to ramiprilat
Half life 2 to 4 hours
Excretion Renal (60%) and fecal (40%)

Ramiprilis an angiotensin-converting enzyme (ACE) inhibitor, used to treat hypertension and congestive heart failure. ACE inhibitors lower the production of angiotensin II, therefore relaxing arterial muscles while at the same time enlarging the arteries, allowing the heart to pump blood more easily, and increasing blood flow due to more blood being pumped into and through larger passageways.

Cautions
Do not take potassium supplements without seeking medical advice.
Do not take during pregnancy

Contraindications
Renovascular disease, severe renal impairment (especially in patients with one kidney or with bilateral renal artery stenosis), volume-depleted patients, history of angioedema while on an ACE inhibitor, pregnancy, hypotension.

Side-effects

  • low blood sugar (in patients taking medication for diabetes), causing sweating or shakiness
  • dry cough
  • dizziness and light-headedness due to low blood pressure
  • decreased sexual drive or ability
  • tiredness and fatigue, especially in the early stages
  • mouth dryness in the early stages
  • nausea, vomiting, diarrhea (persistent in rare cases)
  • fainting
  • change in amount of urine
  • signs of infection (e.g., fever, chills, persistent sore throat)
  • yellowing of eyes or skin, dark urine
  • stomach or abdominal pain

Serious allergic reactions to this drug are unlikely, but immediate medical attention must be sought if they occur. Symptoms of a serious allergic reaction include but are not limited to:

  • rash
  • swelling of the face, mouth, tongue, or throat

In extreme cases, Ramipril may lead to potentially fatal liver problems. It is recommended to start treatment with the lowest dose.

Dose
Patients are started on the lowest dose and titrated up every 3 4 weeks as required.
Dosage comes in the following forms: 1.25 mg, 2.5 mg, 5 mg, 10 mg

Information Associated with Product:
DRUG DESCRIPTION
DOSAGE
SIDE EFFECTS
PRECAUTIONS
INTERACTION
CONSUMER INFORMATION
 
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Ramipril

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