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Ranitidine Hydrochloride

CAS number 66357-35-5

Structure :


Systematic (IUPAC) name
N-(2-[(5-[(dimethylamino)methyl]furan-2-yl)methylthio]ethyl)-N-methyl-2-nitroethene-1,1-diamine

Identifiers

CAS number 66357-35-5
ATC code A02BA02
PubChem 3001055
DrugBank APRD00254
ChemSpider 571454

Chemical data

Formula C13H22N4O3S
Mol. mass 314.4 g/mol

Pharmacokinetic data

Bioavailability 39 to 88%
Metabolism Hepatic
Half life 2–3 hours
Excretion 30–70% Renal

Zantac is used to decrease the production of stomach acid, which may reduce irritation to the stomach lining and help heal ulcers and other gastrointestinal conditions. It's prescribed for the following:

Short-term treatment (4 to 8 weeks) of active ulcers, specifically duodenal ulcers or benign stomach ulcers (also called gastric ulcers).

Maintenance therapy (at a reduced dosage) to help keep the ulcer from coming back after it has healed.

Treatment of conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome and systemic mastocytosis.

Treatment of gastroesophageal reflux disease (also known as GERD, which occurs when stomach acid backs up into the esophagus).

Treating and maintaining healing of erosive esophagitis (severe inflammation of the esophagus).

Two over-the-counter versions, Zantac 75 and Zantac 150, are also available for relieving and preventing heartburn, acid indigestion, and sour stomach. However, the prescription version is still needed for treatment of ulcers, esophagitis, GERD, and other conditions that require monitoring by a doctor.

Most important fact about Ranitidine hydrochloride
Zantac helps to prevent the recurrence of gastric or duodenal ulcers and aids the healing of ulcers that do occur.

How should you take Ranitidine hydrochloride?
Take Ranitidine hydrochloride exactly as prescribed by your doctor. Make sure you follow the diet your doctor recommends.

Dissolve effervescent tablets and granules in 6 to 8 ounces of water before taking them.

You can take an antacid for pain while you are taking Zantac.

• If you miss a dose...
  Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
• Storage instructions...
  Store Ranitidine hydrochloride at room temperature in the container it came in, tightly closed and away from moist places and direct light. Keep Zantac syrup from freezing.
  
  What side effects may occur?
  Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zantac.
  
  Side effects may include:
  Headache, sometimes severe
  
  Why should Ranitidine hydrochloride not be prescribed?
  If you are sensitive to or have ever had an allergic reaction to Zantac or similar drugs, you should not take Ranitidine hydrochloride. Make sure that your doctor is aware of any drug reactions that you have experienced.
  
  Overdosage
  Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
  
  Information concerning Zantac overdosage is limited. However, an abnormal manner of walking, low blood pressure, and exaggerated side effect symptoms may be signs of an overdose. If you experience any of these symptoms, notify your doctor immediately.
   

Information Associated with Product:
DRUG DESCRIPTION DOSAGE SIDE EFFECTS PRECAUTIONS INTERACTION CONSUMER INFORMATION
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