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Ranitidine hydrochlorideis a histamine H2-receptor antagonist that inhibits stomach acid production.

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HOME >> API >> API List 3 >> Ranitidine Hydrochloride >> Drug Description

DRUG DESCRIPTION
Ranitidine Hydrochloride CAS number 66357-35-5

Ranitidine hydrochlorideis a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in treatment of peptic ulcer disease and gastroesophageal reflux disease Ranitidine is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives.

The active ingredient inranitidine hydrochloride (HCl), USP, a histamine H2-receptor antagonist. Chemically it is N[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine, HCl.

The empirical formula is C13H22N4O3S•HCl, representing a molecular weight of 350.87.

Ranitidine HCl is a white to pale yellow, granular substance that is soluble in water. It has a slightly bitter taste and sulfurlike odor.

Ranitidine HCl is used to decrease the production of stomach acid, which may reduce irritation to the stomach lining and help heal ulcers and other gastrointestinal conditions. It's prescribed for the following:

Short-term treatment (4 to 8 weeks) of active ulcers, specifically duodenal ulcers or benign stomach ulcers (also called gastric ulcers).

Maintenance therapy (at a reduced dosage) to help keep the ulcer from coming back after it has healed.
Treatment of conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome and systemic mastocytosis.

Treatment of gastroesophageal reflux disease (also known as GERD, which occurs when stomach acid backs up into the esophagus).

Treating and maintaining healing of erosive esophagitis (severe inflammation of the esophagus)

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