Cas No. [58-55-9]

DRUG INTERACTIONS: Certain groups of patients metabolize theophylline slowly, and can develop elevated blood levels and potential toxicity even on usual doses. These patients include those with liver disease, older men with chronic lung diseases, infants, patients with high fever or heart failure, and patients taking other medications that increase blood theophylline levels. Examples of medications that can elevate theophylline blood levels include ephedrine, allopurinol (Zyloprim), cimetidine (Tagamet), ciprofloxacin (Cipro), erythromycin, oral contraceptives, and propranolol (Inderal). Theophylline toxicity can cause nausea, vomiting, insomnia, seizures, agitation and life- threatening heart rhythm abnormalities. Theophylline should be used cautiously in patients with high blood pressure, peptic ulcer disease, seizure disorders, and serious heart disease, especially with heart rhythm problems.

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