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Quinine Sulfate

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HOME >> API >> API List 3 >> Quinine Sulfate >> Dosage

DOSAGE
Quinine Sulfate CAS number 130-95-0

Take this medication by mouth with or without food exactly as prescribed by your doctor. This medication is usually taken every 8 hours for 7 days or as directed by your doctor. If you have stomach upset with quinine, take it with food.

Dosage is based on your kidney function, medical condition, and response to therapy.

It is very important to continue taking this medication exactly as prescribed by your doctor. This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.

Quinine is a basic amine and is therefore always presented as a salt. Various preparations that exist include the hydrochloride, dihydrochloride, sulfate, bisulfate and gluconate. This makes quinine dosing very complicated, because each of the salts has a different weight.

The following amounts of each form are equal:

* quinine base 100 mg
* quinine bisulfate 169 mg
* quinine dihydrochloride 122 mg
* quinine hydrochloride 111 mg
* quinine sulfate

quinine gluconate 160 mgAll quinine salts may be given orally or intravenously (IV); quinine gluconate may also be given intramuscularly (IM) or rectally (PR).

The main problem with the rectal route is that the dose can be expelled before it is completely absorbed; this can be corrected by giving a half dose again.

The IV dose of quinine is 8 mg/kg of quinine base every eight hours; the IM dose is 12.8 mg/kg of quinine base twice daily; the PR dose is 20 mg/kg of quinine base twice daily. Treatment should be given for seven days.

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