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HOME >> Pharmaceuticals API List 3 >> Zonisamide >> Dosage

DOSAGE
Zonisamide CAS number 68291-97-4

Zonisamide are recommended as adjunctive therapy for the treatment of partial seizures in adults. Safety and efficacy in pediatric patients below the age of 16 have not been established. Zonisamide should be administered once or twice daily, using 25 mg, 50 mg or 100 mg . Zonisamide are given orally and can be taken with or without food. should be swallowed whole.

Adults over Age 16:

The prescriber should be aware that, because of the long half-life of Zonisamide, up to two weeks may be required to achieve steady state levels upon reaching a stable dose or following dosage adjustment. Although the regimen described below is one that has been shown to be tolerated, the prescriber may wish to prolong the duration of treatment at the lower doses in order to fully assess the effects of Zonisamide at steady state, noting that many of the side effects of Zonisamide are more frequent at doses of 300 mg per day and above. Although there is some evidence of greater response at doses above 100-200 mg/day, the increase appears small and formal dose-response studies have not been conducted.

Patients with Renal or Hepatic Disease:

Because Zonisamide is metabolized in the liver and excreted by the kidneys, patients with renal or hepatic disease should be treated with caution, and might require slower titration and more frequent monitoring.

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