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HOME >> Chemicals >> Chemicals List 1 >> N-Phenethyl-4-piperidinone


CAS number 39742-60-4

N-Phenethyl-4-piperidinone formula C13H17NO
N-Phenethyl-4-piperidinone powder

N-Phenethyl-4-piperidinone IUPAC name
Other names N-Phenethyl-4-piperidinone
Abbreviations NPP


CAS number [39742-60-4]


Molecular formula C13H17NO
Molar mass 203.28 g mol−1


EU classification Flammable (F)
Harmful (Xn)
Dangerous for
the environment (N)

N-Phenethyl-4-piperidinone (NPP) is a derivative of 4-piperidinone with the molecular formula C13H17NO. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs such as fentanyl.

Because of its use in the illicit manufacture of fentanyl, NPP was placed onto the list of controlled chemicals in the USA in 2007, and possession and sales of this compound are now heavily restricted.



* 4-piperidinone hydrochloride was first reacted with phenethyl bromide to give N-phenethyl-4-piperidinone (NPP).
* Treatment of the NPP intermediate with aniline.
* Reduction with sodium borohydride afforded 4-anilino-N-phenethyl-piperidine (ANPP).
* A final acylation reaction between ANPP and propionic anhydride led to the fentanyl.

Analogues: Alfentanil

* Opioid analgesic (painkiller) with rapid onset of action
* Used for surgery
* Injectable alfentanil marketed under brand name Alfenta
* Can last around 30 minutes


* Marked under the name Wildnil as a tranquilizer for large animals
* 10,000 times stronger than morphine
* 100 times stronger than fentanyl
* Discovered by Janssen Pharmaceutica


* Opioid analgesic (painkiller) marked under the name Ultiva
* Extremely rapid onset and offset
* Blood concentration decreases by 50% in 3-6 minutes after a one-minute infusion of remifentanil


* 5-10 times more potent than fentanyl
* Marketed as Sufenta and Sufentil
* Sometimes used during anesthesia
* Transdermal patch for chronic pain sufferers currently in development

A narcotic analgesic used in combination with other drugs before, during, or following surgery and also for chronic pain management.


Note /Government Notification: These chemicals are designated as those that are used in the manufacture of the controlled substances and are important to the manufacture of the substances. For any (Control Substance) products Import and Export *** subjected to your country government laws /control substance ACT.
Information: The information on this web page is provided to help you to work safely, but it is intended to be an overview of hazards, not a replacement for a full Material Safety Data Sheet (MSDS). MSDS forms can be downloaded from the web sites of many chemical suppliers. ,also that the information on the PTCL Safety web site, where this page was hosted, has been copied onto many other sites, often without permission. If you have any doubts about the veracity of the information that you are viewing, or have any queries, please check the URL that your web browser displays for this page. If the URL begins " Benzoate.htm/" the page is maintained by the Safety Officer in Physical Chemistry at Oxford University. If not, this page is a copy made by some other person and we have no responsibility for it.
The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970.[1] The CSA is the federal U.S. drug policy under which the manufacture, importation, possession, use and distribution of certain substances is regulated. The Act also served as the national implementing legislation for the Single Convention on Narcotic Drugs

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